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How Supplements Help and Why They May Affect Cancer
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Supplements: Supporting Health and Cancer Research
How Supplements Help and Why They May Affect Cancer
Milk Thistle
How It Helps: Supports liver detoxification, antioxidant, may aid chemotherapy recovery. This supplement is often used for its supports liver detoxification effects, which may support overall health and resilience.
Typical Dosage: 150-300 mg/day (silymarin). This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Protects liver from chemo toxicity, reduces oxidative damage.. Active ingredient is silymarin, best taken with food. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Sulforaphane
How It Helps: Supports detoxification, antioxidant, may have anti-cancer properties. This supplement is often used for its supports detoxification effects, which may support overall health and resilience.
Typical Dosage: 10-40 mg/day (from supplements). This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Activates Nrf2, enhancing detox and reducing oxidative stress in tumors.. Found in broccoli sprouts and cruciferous vegetables. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Black Seed Oil
How It Helps: Anti-inflammatory, antioxidant, potential anti-cancer properties. This supplement is often used for its anti-inflammatory effects, which may support overall health and resilience.
Typical Dosage: 1-3 tsp/day (5-15 mL). This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Induces apoptosis via p53 and caspase activation, inhibits tumor growth.. Active compound is thymoquinone; best taken with food. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Curcumin
How It Helps: Anti-inflammatory, antioxidant, potential cancer-fighting properties. This supplement is often used for its anti-inflammatory effects, which may support overall health and resilience.
Typical Dosage: 500-2000 mg/day. This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Inhibits NF-κB and COX-2 pathways, reducing inflammation and tumor growth.. Best absorbed with black pepper extract (piperine). These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Quercetin
How It Helps: Antioxidant, anti-inflammatory, may help suppress tumor growth. This supplement is often used for its antioxidant effects, which may support overall health and resilience.
Typical Dosage: 500-1000 mg/day. This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Blocks PI3K/Akt signaling, inducing apoptosis in cancer cells.. Often combined with bromelain for better absorption. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Bromelain
How It Helps: Anti-inflammatory, supports digestion, potential anti-cancer properties. This supplement is often used for its anti-inflammatory effects, which may support overall health and resilience.
Typical Dosage: 500-1000 mg/day. This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Inhibits NF-κB and COX-2, reduces metastasis and tumor invasion.. Often paired with quercetin; derived from pineapple. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
EGCG (Green Tea Extract)
How It Helps: Antioxidant, supports immune function, may inhibit cancer cell growth. This supplement is often used for its antioxidant effects, which may support overall health and resilience.
Typical Dosage: 200-800 mg/day. This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Downregulates VEGF, inhibiting angiogenesis and tumor spread.. Best taken on an empty stomach for maximum absorption. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Vitamin C
How It Helps: Antioxidant, supports immune function, may enhance cancer therapy. This supplement is often used for its antioxidant effects, which may support overall health and resilience.
Typical Dosage: 1000-2000 mg/day (oral); 10-50 g IV (cancer-related). This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Generates hydrogen peroxide in high doses, selectively toxic to cancer cells.. High doses may require IV for cancer effects. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Resveratrol
How It Helps: Antioxidant, supports cellular health, potential anti-cancer effects. This supplement is often used for its antioxidant effects, which may support overall health and resilience.
Typical Dosage: 100-500 mg/day. This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Activates SIRT1 and p53, promoting apoptosis and cell cycle arrest.. Found in red grapes, wine, and Japanese knotweed. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Omega-3 Fatty Acids (EPA/DHA)
How It Helps: Anti-inflammatory, supports immune function, may inhibit tumor growth. This supplement is often used for its anti-inflammatory effects, which may support overall health and resilience.
Typical Dosage: 1000-3000 mg/day (EPA+DHA). This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Reduces prostaglandin E2 via COX inhibition, induces apoptosis.. Found in fish oil; best with low omega-6 intake. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Vitamin D3
How It Helps: Supports immune function, may reduce cancer risk. This supplement is often used for its supports immune function effects, which may support overall health and resilience.
Typical Dosage: 1000-4000 IU/day. This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Regulates cell differentiation and proliferation via VDR signaling.. Best taken with fat for proper absorption. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Astragalus
How It Helps: Immune-boosting, anti-inflammatory, potential anti-cancer effects. This supplement is often used for its immune-boosting effects, which may support overall health and resilience.
Typical Dosage: 500-1000 mg/day (extract). This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Stimulates NK cells and T-cells, inhibits tumor growth.. Often used in TCM; best as root extract. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Melatonin
How It Helps: Regulates sleep, supports immune function, potential anti-cancer effects. This supplement is often used for its regulates sleep effects, which may support overall health and resilience.
Typical Dosage: 3-20 mg/day (cancer-related). This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Inhibits tumor metabolism and enhances immune surveillance.. Higher doses may be needed for therapeutic effects. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Ashwagandha
How It Helps: Adaptogenic, anti-stress, potential anti-cancer properties. This supplement is often used for its adaptogenic effects, which may support overall health and resilience.
Typical Dosage: 300-600 mg/day (extract). This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Inhibits STAT3 and NF-κB, promotes apoptosis.. Best taken at night; may enhance sleep. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Berberine
How It Helps: Supports metabolic health, may have anti-cancer properties. This supplement is often used for its supports metabolic health effects, which may support overall health and resilience.
Typical Dosage: 500-1500 mg/day. This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Targets AMPK, disrupting cancer cell energy production.. Commonly used for blood sugar regulation and gut health. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Ginger
How It Helps: Anti-inflammatory, antioxidant, may reduce nausea and cancer growth. This supplement is often used for its anti-inflammatory effects, which may support overall health and resilience.
Typical Dosage: 1000-2000 mg/day (extract). This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Inhibits NF-κB and COX-2, induces apoptosis.. Can be taken as tea or capsules. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Selenium
How It Helps: Antioxidant, supports immune function, may reduce cancer risk. This supplement is often used for its antioxidant effects, which may support overall health and resilience.
Typical Dosage: 100-200 mcg/day. This range reflects common use in health supplements and preclinical studies, though therapeutic doses for cancer may vary and require medical oversight.
Why It May Help with Cancer: Enhances glutathione peroxidase, protects DNA, induces apoptosis.. Avoid excess (>400 mcg/day) due to toxicity. These effects are primarily observed in lab or animal models, suggesting potential rather than proven efficacy in humans.
Support Against Herxheimer Reactions
The Herxheimer reaction (herxing) occurs when dying pathogens or cancer cells release toxins faster than the body can eliminate them, often during detox or antimicrobial therapies. Symptoms include fatigue, inflammation, and flu-like effects. Several supplements may help mitigate these reactions by supporting detoxification, reducing inflammation, or stabilizing the body’s response:
Milk Thistle: Supports liver detox, reducing toxin buildup during die-off.
Sulforaphane: Aids liver detox pathways, reducing herx severity.
Black Seed Oil: Reduces inflammation and supports immune response during detox.
Curcumin: Reduces inflammation from toxin release.
Quercetin: Mitigates inflammation and oxidative stress from die-off.
Bromelain: Eases inflammation and digestive stress during detox.
EGCG (Green Tea Extract): Boosts antioxidant capacity to handle toxin overload.
Vitamin C: Boosts antioxidant capacity, reduces oxidative stress from die-off.
Resveratrol: Supports cellular repair during detox stress.
Omega-3 Fatty Acids (EPA/DHA): Lowers inflammation from toxin release.
Vitamin D3: Enhances immune response to manage die-off symptoms.
Astragalus: Supports immune resilience during detox stress.
Melatonin: Improves sleep and immune balance during detox.
Ashwagandha: Reduces stress and fatigue during detox.
Berberine: Stabilizes gut flora, easing digestive herx symptoms.
Ginger: Eases nausea and digestive upset from herxing.
Selenium: Boosts antioxidant defense against toxin overload.